Place potato wedges in a large bowl. Cover with cold water by at least 2 inches. Soak the potatoes for at least half an hour. Drain and pat dry with a clean dish towel.
Preheat the air fryer to 400°F.
Return the potato wedges to the empty, dry bowl. Toss with the oil, salt, garlic powder, black pepper, and crushed red pepper flakes.
Transfer the potatoes to the air fryer basket, working in batches if necessary to avoid crowding the basket. Air fry for 15 minutes, tossing gently halfway through.